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MAD YET? FOUCHI A YEAR AGO LEAKED EMAIL HE WAS TAKING 6000IU

Michael Williamson
Michael Williamson - 52 Views
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52 Views
Published on 27 Oct 2021 / In Health

Lower levels of vitamin D, higher rates of death
Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Adult Patients With Existing Cardiovascular Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496747/
Observational study, non-interventional
Background
Vitamin D, lower levels, common in patients with cardiovascular disease (CVD)
Study of patients with existing CVD
Prospectively examine the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with,

All-cause mortality and, cause-specific mortality
Methods

N = 37,079 patients with CVD from the UK
Biobank study
From a prospective cohort of half a million, aged 40–69 years

https://www.ukbiobank.ac.uk

CVD
Coronary heart disease
Atrial fibrillation
Heart failure
Stroke
Results
Among 37,079 patients with CVD at baseline, 57.5% were vitamin D deficient

Deficient, 25[OH]D less than 50 nmol/L (less than 20ng/ml)
Median follow-up of 11.7 years
Deaths that occurred = 6,319 total
2,161 deaths from CVD
2,230 deaths from cancer
623 deaths from respiratory disease
1,305 other-cause deaths
Non-linear inverse associations

For all-cause mortality
Cancer mortality
Respiratory disease mortality
Other-cause mortality
That is deaths went up as vitamin D levels went down
(P-non-linearity less than 0.01)
Approximately linear inverse associations for CVD

That is deaths went up as vitamin D levels went down
(P-non-linearity = 0.074)
Among CVD patients with vitamin D deficiency
For every 10 nmol/L increment in serum 25(OH)D concentrations,
There was an associated 12% reduced risk for all-cause mortality
There was an associated 9% reduced risk for CVD mortality.
In patients with vitamin D deficiency
Per 10 nmol/L increase in serum 25(OH)D levels,
was associated with a lower risk of mortality from (aHR]; 95% CI)
All-cause 0.88

CVD 0.91
Cancer 0.90
Respiratory diseases 0.81
Other causes 0.81
Multivariable Cox regression models
Age, sex, alcohol, BMI, GFR, education, ethnicity, household income, smoking status, healthy diet score, diabetes (and meds), HbA1c, duration of CVD, blood pressure (and meds), lipid profile (and meds), triglycerides, cholesterol

Conclusion
Among patients with existing CVD,
increasing levels in serum 25(OH)D,
were independently associated with a decreased risk of all-cause and cause-specific mortality
These findings suggest that elevated serum 25(OH)D concentration benefits CVD patients with vitamin D deficiency.

Therefore: Patients with vitamin D deficiency may benefit more from an increase in serum levels,
than those with CVD and serum 25(OH)D levels of less than 50 nmol/L (less than 20ng/ml)
Our findings provided novel clues
awaiting further validation in clinical trials.

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